A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome

Elizabeth Batiuk; Mikelle Bassett; Melanie Hakar; Henry C Lin; Anna K Hunter

doi:10.1186/s12887-023-03929-y

A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome

BMC Pediatr. 2023 Apr 21;23(1):189. doi: 10.1186/s12887-023-03929-y.

Authors

Elizabeth Batiuk¹, Mikelle Bassett², Melanie Hakar³, Henry C Lin², Anna K Hunter²

Affiliations

¹ Internal Medicine Residency Program, Olive View-UCLA Medical Center, Sylmar, USA. edbatiuk@gmail.com.
² Department of Pediatrics, Oregon Health & Science University, Portland, USA.
³ Department of Pathology, Oregon Health & Science University, Portland, USA.

Abstract

Background: Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder that increases risk of hematological malignancy. Primary gastric malignancies are exceedingly rare in pediatric patients and not typically high on the differential of abdominal pain.

Case presentation: A 14-year-old male with NBS presented with persistent abdominal pain and was diagnosed with primary Hodgkin disease of the stomach.

Conclusions: In pediatric patients with predisposition to malignancies, such as those with underlying chromosome instability disorders, all symptoms must be carefully considered.

Keywords: Case Report; Childhood cancer; Hodgkin disease; Malnutrition; Nijmegen Breakage Syndrome; Primary gastric lymphoma.

Publication types

Case Reports

MeSH terms

Adolescent
Child
Genotype
Hodgkin Disease* / complications
Hodgkin Disease* / diagnosis
Humans
Male
Nijmegen Breakage Syndrome* / complications
Nijmegen Breakage Syndrome* / diagnosis
Nijmegen Breakage Syndrome* / genetics